High Shear Stress‐Induced Endothelial Piezo1 Downregulation Promotes Intracranial Aneurysm Formation via the <scp>PDGF</scp> ‐ <scp>BB</scp> / <scp>PDGFRβ</scp> Paracrine Signaling Pathway

HSS downregulates Piezo1 expression in ECs, which subsequently enhances PDGF-BB expression through the YAP/β-catenin signaling pathway. The elevated PDGF-BB facilitates phenotypic transition of VSMCs via PDGFRβ binding, ultimately contributing to IA formation.

Authors

Institutions

Publication Details

Journal
CNS Neuroscience & Therapeutics
Published
2025-12-01
DOI
https://doi.org/10.1002/cns.70715
Primary Topic
Axon Guidance and Neuronal Signaling
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

High Shear Stress‐Induced Endothelial Piezo1 Downregulation Promotes Intracranial Aneurysm Formation via the PDGF ‐ BB / PDGFRβ Paracrine Signaling Pathway

Shijie Zhu, Fengfeng Xu, Haishuang Tang, Qinghai Huang et al.
CNS Neuroscience & Therapeutics
Axon Guidance and Neuronal Signaling
article

High Shear Stress‐Induced Endothelial Piezo1 Downregulation Promotes Intracranial Aneurysm Formation via the PDGF ‐ BB / PDGFRβ Paracrine Signaling Pathway

Shijie Zhu, Fengfeng Xu, Haishuang Tang, Qinghai Huang, Sisi Li, Zhiwen Lu, Xiaohua Yang, Chuanchuan Wang
article en

Abstract

HSS downregulates Piezo1 expression in ECs, which subsequently enhances PDGF-BB expression through the YAP/β-catenin signaling pathway. The elevated PDGF-BB facilitates phenotypic transition of VSMCs via PDGFRβ binding, ultimately contributing to IA formation.

CNS Neuroscience & TherapeuticsVol. 31(12)
Naval Medical Research Command (US), Second Military Medical University (CN), Fudan University (CN), Shanghai Chest Hospital (CN), Shanghai Mental Health Center (CN), Beijing Tian Tan Hospital (CN), Changhai Hospital (CN), Huashan Hospital (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 36%
Axon Guidance and Neuronal Signaling
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

High Shear Stress‐Induced Endothelial Piezo1 Downregulation Promotes Intracranial Aneurysm Formation via the <scp>PDGF</scp> ‐ <scp>BB</scp> / <scp>PDGFRβ</scp> Paracrine Signaling Pathway — Shijie Zhu, Fengfeng Xu, et al. · CNS Neuroscience & Therapeutics (2025) | TGRS Research Map | TGRS