Synthesis and Biological Evaluation of a Caffeic Acid Phenethyl Ester Derivatives as Anti-Hepatocellular Carcinoma Agents via Inhibition of Mitochondrial Respiration and Disruption of Cellular Metabolism
Our findings establish a foundational rationale for further pharmaceutical development of CAPE derivates as a promising therapeutic candidate for hepatocellular carcinoma.
Authors
- G. Zhang
- Hao Dong (ORCID: https://orcid.org/0000-0002-7332-1505)
- Xinyue Gu
- Yi Zhou (ORCID: https://orcid.org/0000-0002-0273-007X)
- Dabao Xu (ORCID: https://orcid.org/0000-0002-8380-3057)
- Weiwei Diao (ORCID: https://orcid.org/0000-0002-5042-3322)
- Yi Liu (ORCID: https://orcid.org/0000-0002-1058-0382)
- Dongyue Jiang
- Ruixin Li
- Xiyunyi Cai
- Chenjie Feng
- Liang Wu
- Jiacheng Wen
- Yuan Gao
- Weijia Xie
Institutions
- Johns Hopkins University (US)
- China Pharmaceutical University (CN)
Publication Details
- Journal
- Cancers
- Published
- 2025-12-27
- DOI
- https://doi.org/10.3390/cancers18010092
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00