Comparative Study between Fentanyl and ketamine as Co-induction Agent with Propofol for Laryngeal Mask Airway Insertion

Background: An essential component of effective airway control is the laryngeal mask airway (LMA). A necessary part of the anesthesiologist's job is to keep the airway open while the surgery is underway. For the unique needs of outpatient anesthesia, supraglottic airway devices (SGAs) are an excellent alternative to endotracheal intubation. Aim: To compare the hemodynamic effects and ease of LMA insertion between ketamine and fentanyl as a co-induction agent with propofol. Patients and Methods: Our randomized, double-blind study took place at Beni-Suef University Hospital after receiving approval from the Research Ethics Committee at the Faculty of Medicine, Beni-Suef University. The study included 90 patients, split into two groups: Group A, with 45 patients who were given fentanyl and propofol, and Group B, with 45 patients who received ketamine and propofol. Results: Regarding systolic blood pressure (SBP) In group A, the post LMA insertion mean SBP was 105.44 with SD 9.77, While in group B, the post insertion mean SBP was 127.67 with SD 13.5, showing significant statically differences with p values 0.0001. Regarding heart rate (HR). In group A the post LMA insertion mean HR was 76.24 with SD 11.50. while in group B, the post insertion mean HR was 92.44 with SD 11.99, showing significant statically differences with p values 0.0001. Conclusion: When comparing the two drugs, ketamine not only provided favorable insertion conditions but also offered better hemodynamic stability compared to fentanyl, making it a valuable choice for maintaining patient stability during the procedure.