Chitinase-3-like 1 is associated with stunting and developmental delay in HIV-exposed but uninfected Ugandan children
Chronic systemic inflammation may affect linear growth and neurodevelopment in children who are HIV-exposed but uninfected (cHEU). We examined plasma concentrations of neutrophil activation marker chitinase-3-like protein 1 (CHI3L1) levels in 153 Ugandan cHEU. At 18 months of age, CHI3L1 levels were inversely correlated with height-for-age z scores (τB = -0.17, P = 0.0035) and a normalized developmental score (τB = -0.20, P = 0.00027). CHI3L1 appears to be a marker of adverse growth and development in cHEU.
Authors
- Andrea L. Conroy (ORCID: https://orcid.org/0000-0002-5328-6511)
- M. F. Hawkes (ORCID: https://orcid.org/0000-0001-8762-995X)
- J Brophy
- Robert O. Opoka (ORCID: https://orcid.org/0000-0003-3240-2058)
- Fatima Kakkar
- Elspeth MacBain
- Sophie Namasopo
Institutions
- University of British Columbia (CA)
- Children's Hospital of Eastern Ontario (CA)
- Kabale Hospital (UG)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- World Health Organization - Uganda (UG)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- AIDS
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1097/qad.0000000000004389
- Citations
- 1
- Primary Topic
- Studies on Chitinases and Chitosanases
- Type
- article
- Field-Weighted Citation Impact
- 0.81