Nerofe+ldDox releases c-Jun from nuclear ST2 to reprogram the immune microenvironment in mtKRAS tumors
Nerofe+ldDox reprograms the immune microenvironment of mtKRAS tumors by releasing c-Jun from inhibitory nuclear ST2, enabling expression of IL-2 and miR-217. This "nuclear immunomodulation" promotes immune cell infiltration and downregulates KRAS expression, highlighting Nerofe+ldDox as a promising therapeutic approach for mtKRAS-driven cancers.
Authors
- Stephen V. Liu (ORCID: https://orcid.org/0000-0002-4852-3914)
- Benjamin A. Weinberg (ORCID: https://orcid.org/0000-0002-0408-4817)
- Yoram Devary
- Joel Ohana
- Uziel Sandler
Institutions
- Georgetown University (US)
- Jerusalem College of Technology (IL)
- Georgetown University Medical Center (US)
Publication Details
- Journal
- Oncotarget
- Published
- 2025-12-24
- DOI
- https://doi.org/10.18632/oncotarget.28820
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00