Sleep duration promotes resistance and resilience to tau in older women at risk for Alzheimer's disease
Sleep was measured via wrist actigraphy, tau via PET imaging, and memory with a composite score. Longer sleep attenuated the link between APOE ε4 carriership and tau PET across Braak regions. Greater sleep duration weakened the negative impact of tau on memory performance. This is the first study to examine sleep in AD resistance and resilience among older women at heightened risk.
Authors
- Ella T. Lifset (ORCID: https://orcid.org/0000-0003-2640-3206)
- Erin E. Sundermann (ORCID: https://orcid.org/0000-0001-5821-8035)
- Kitty K. Lui (ORCID: https://orcid.org/0000-0001-7586-0118)
- Jordan Stiver (ORCID: https://orcid.org/0000-0002-9568-3574)
- Charlotte S. Rivera
- Melanie A Dratva
- Xin Wang (ORCID: https://orcid.org/0000-0003-0314-9268)
- Nadine C. Heyworth
- Atul Malhotra
- Michael L. Thomas
- Sarah J. Banks
Institutions
- University of California, Los Angeles (US)
- San Diego State University (US)
- University of California System (US)
- University of California San Diego (US)
- Colorado State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.71051
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00