Elevated sCD14 in cerebrospinal fluid: a surrogate marker for HIV-associated neurocognitive disorders in Brazil
This study investigates cerebrospinal fluid (CSF) biomarkers associated with HIV-associated neurocognitive disorders (HAND) in people with HIV (PWH) in Brazil. Among 79 HIV-positive participants and 7 negative controls, elevated levels of inflammatory cytokines and soluble CD14 (sCD14) were found. The sCD14 showed promise as a diagnostic marker, and combined with other proinflammatory markers, may improve early detection and monitoring of HAND.
Authors
- A. Penalva de Oliveira
- Maria Rita Polo Gascón (ORCID: https://orcid.org/0000-0002-3260-9000)
- Y. Tang
- Augusto Penalva
- Gabriela Silva Prates
- Carlos Fernando Apoliano (ORCID: https://orcid.org/0000-0002-3963-7661)
- Víctor Ângelo Folgosi (ORCID: https://orcid.org/0000-0002-0114-7587)
- Camila Malta Romano (ORCID: https://orcid.org/0000-0003-4550-1987)
- Guochun Jiang (ORCID: https://orcid.org/0000-0003-1911-5089)
- José Ernesto Vidal (ORCID: https://orcid.org/0000-0001-5000-717X)
- Jerusa Smid
- Rosa M. do N. Marcusso
- Jorge Casseb
Institutions
- Instituto de Infectologia Emílio Ribas (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- AIDS
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1097/qad.0000000000004368
- Citations
- 1
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.04