212 Research Priorities for Cancers of the Oesophagus and Stomach: Recommendations from a United Kingdom & Ireland Patient and Healthcare Professional Partnership Exercise

Abstract Aim Oesophagogastric (OG) cancers are a major cause of morbidity and mortality. Research is crucial to improving outcomes but to maximise value and impact, areas of focus should be prioritised in partnership with patients. Method We undertook the first comprehensive analysis of patient and healthcare professional (HCP) priorities for research across the domains of prevention, diagnosis and staging, treatment, palliative care and survivorship. An initial scoping survey sought research uncertainties from HCPs and patients. These were consolidated into true research uncertainties, each confirmed by systematic review, and their potential impact scored by HCPs. A domain-specific weighting reflecting patient values was then applied to prioritise identified uncertainties. Results In total, 835 (395 HCP, 440 patient) responses were received, with 3906 suggested priorities consolidated to 92 true research uncertainties. HCP respondents represented 19 community and hospital professions and specialties involved in OG cancer care. Across the domains, patient weighting changed 22.2%-46.3% of the priority rankings established by HCP scoring. There was a high degree of agreement between individual HCPs as well as between HCPs and patients for the highest-ranked research uncertainties. These focused on selecting those who should be screened, identifying causes for late diagnosis, determining the most effective treatment combinations, optimizing nutrition across multiple settings and evaluating the long-term impact of prehabilitation. Conclusions This work highlights the impact of patient input on HCP-ranked research priorities and provides a robust list of priorities to guide funders, policy makers and researchers to support and undertake impactful research focused on OG cancer.

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Publication Details

Journal
British journal of surgery
Published
2025-12-01
DOI
https://doi.org/10.1093/bjs/znaf270.167
Primary Topic
Esophageal Cancer Research and Treatment
Type
article
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article

212 Research Priorities for Cancers of the Oesophagus and Stomach: Recommendations from a United Kingdom & Ireland Patient and Healthcare Professional Partnership Exercise

Pinkie Chambers, Sarah Helene Gwynne, Heike I. Grabsch, Greg Rubin et al.
British journal of surgery
Esophageal Cancer Research and Treatment
article

212 Research Priorities for Cancers of the Oesophagus and Stomach: Recommendations from a United Kingdom & Ireland Patient and Healthcare Professional Partnership Exercise

Pinkie Chambers, Sarah Helene Gwynne, Heike I. Grabsch, Greg Rubin, Karen Campbell, Dylan Peter McClurg, Francesca D. Ciccarelli, Richard Calvin Turkington, Laura Tincknell, Fiona M Walter, Wee Han Ng, N Trudgill, Pradeep Bhandari, Vicky Goh, Lauren Leigh-Doyle, Christopher John Peters, Helen G. Coleman, Catriona R Mayland, Alan Moss, Jessica A. Williams, Mimi McCord, Marnix Jansen, Michael P. W. Grocott, Emily Adam, John M. Dunn, Farida Malik, T Underwood, Claire Lamb, Siddharth Rananaware, Pernilla Lagergren, Rebecca Fitzgerald, Kieran Foley, Joanne Reid, Trevor Graham, Jessie Elliott, Elizabeth Smyth, Somnath Mukherjee, Russell Petty, Tom Crosby, Eileen Rubery, Christopher Jones, Jo Harvey
article en

Abstract

Abstract Aim Oesophagogastric (OG) cancers are a major cause of morbidity and mortality. Research is crucial to improving outcomes but to maximise value and impact, areas of focus should be prioritised in partnership with patients. Method We undertook the first comprehensive analysis of patient and healthcare professional (HCP) priorities for research across the domains of prevention, diagnosis and staging, treatment, palliative care and survivorship. An initial scoping survey sought research uncertainties from HCPs and patients. These were consolidated into true research uncertainties, each confirmed by systematic review, and their potential impact scored by HCPs. A domain-specific weighting reflecting patient values was then applied to prioritise identified uncertainties. Results In total, 835 (395 HCP, 440 patient) responses were received, with 3906 suggested priorities consolidated to 92 true research uncertainties. HCP respondents represented 19 community and hospital professions and specialties involved in OG cancer care. Across the domains, patient weighting changed 22.2%-46.3% of the priority rankings established by HCP scoring. There was a high degree of agreement between individual HCPs as well as between HCPs and patients for the highest-ranked research uncertainties. These focused on selecting those who should be screened, identifying causes for late diagnosis, determining the most effective treatment combinations, optimizing nutrition across multiple settings and evaluating the long-term impact of prehabilitation. Conclusions This work highlights the impact of patient input on HCP-ranked research priorities and provides a robust list of priorities to guide funders, policy makers and researchers to support and undertake impactful research focused on OG cancer.

British journal of surgeryVol. 112(Supplement_17)
Queen's University Belfast (GB), University of Leeds (GB), Royal Marsden NHS Foundation Trust (GB), University College London Hospitals NHS Foundation Trust (GB), Institute of Cancer Research (GB), Imperial College Healthcare NHS Trust (GB), Queen Mary University of London (GB), University of Dundee (GB), King's College London (GB), Guy's and St Thomas' NHS Foundation Trust (GB), Trinity College Dublin (IE), University of Cambridge (GB), Edinburgh Napier University (GB), Sandwell & West Birmingham Hospitals NHS Trust (GB), Cambridge University Hospitals NHS Foundation Trust (GB), University of Bristol (GB), Swansea University (GB), Portsmouth Hospitals NHS Trust (GB), Institute of Cancer Research (CA), Heartland Cancer Research (US), Cambridgeshire County Council (GB), East Sussex Healthcare NHS Trust (GB), Aberdeenshire Council (GB), Royal Surrey NHS Foundation Trust (GB), Oxford University Hospitals NHS Trust (GB), CRUK Lung Cancer Centre of Excellence (GB), Velindre Cancer Centre (GB), The Cancer Treatment Center (US), University of Southampton (GB), University College London (GB), Imperial College London (GB), University of Newcastle Australia (AU), Newcastle University (GB), University of Sheffield (GB), Action Contre la Faim (FR)
Partnerships for the goals
Openalex Percentile: Top 26%
Esophageal Cancer Research and Treatment
DOISourceOpenAlex
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