Hypoxia inhibits intervertebral disc degeneration by maintaining autophagy circadian rhythm via the HIF1α-PER2-mTOR pathway
Our study demonstrates that hypoxia maintains the intrinsic CR and autophagy rhythm through the HIF-1α/PER2/mTOR pathway to prevent IDD.
Authors
- Zhirui Dong (ORCID: https://orcid.org/0009-0006-1235-6559)
- Wang Ding (ORCID: https://orcid.org/0000-0003-2138-1634)
- Yu-Kai Huang (ORCID: https://orcid.org/0000-0001-5377-1405)
- Yuxiang Ge (ORCID: https://orcid.org/0000-0002-4292-9905)
- Guang-Cheng Yuan
- Nong Chen
- Li-Bo Jiang
- Qi-Chen Zhang
- Heng-Jie Zeng
- Jian Dong
- Tai-Wei Zhang
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Jinshan Hospital of Fudan University (CN)
- Minhang District Central Hospital (CN)
- Shanghai Xuhui Central Hospital (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jare.2025.12.036
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00