Application of machine learning in the discovery of antimicrobial peptides: exploring their potential for ulcerative colitis therapy

Our findings demonstrate that machine learning-guided discovery of AMPs is a viable approach to identify promising therapeutic agents for UC. By integrating multi-omics analyses, we reveal potential microbiota-mediated mechanisms underlying AMP efficacy. These insights provide a strong foundation for advancing AMP-based strategies in UC management.

Authors

Yifan Liu (ORCID: https://orcid.org/0000-0001-9368-3047)
Haiyuan Yang (ORCID: https://orcid.org/0000-0002-5714-4174)
Ziyi Guo (ORCID: https://orcid.org/0000-0002-0811-5086)
Ziwei Wang
Jiamei Wang
Pengfei Cui
Hui Miao
Jiaqi Wang
Shihu Chen
Hongyue Ma

Institutions

Ocean University of China (CN)

Publication Details

Journal: eGastroenterology
Published: 2025-10-01
DOI: https://doi.org/10.1136/egastro-2025-100253
Primary Topic: Antimicrobial Peptides and Activities
Type: article
Field-Weighted Citation Impact: 0.00

Funders

National Natural Science Foundation of China

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article

Application of machine learning in the discovery of antimicrobial peptides: exploring their potential for ulcerative colitis therapy

Yifan Liu, Haiyuan Yang, Ziyi Guo, Ziwei Wang et al.

Oct 1, 2025

eGastroenterology

Antimicrobial Peptides and Activities

article

Application of machine learning in the discovery of antimicrobial peptides: exploring their potential for ulcerative colitis therapy

Yifan Liu, Haiyuan Yang, Ziyi Guo, Ziwei Wang, Jiamei Wang, Pengfei Cui, Hui Miao, Jiaqi Wang, Shihu Chen, Hongyue Ma

October 1, 2025article en

Abstract

Our findings demonstrate that machine learning-guided discovery of AMPs is a viable approach to identify promising therapeutic agents for UC. By integrating multi-omics analyses, we reveal potential microbiota-mediated mechanisms underlying AMP efficacy. These insights provide a strong foundation for advancing AMP-based strategies in UC management.

eGastroenterologyVol. 3(4)

Ocean University of China (CN)

National Natural Science Foundation of China

Good health and well-being

Openalex Percentile: Top 31%

Antimicrobial Peptides and Activities

DOI Open Access PDF OpenAlex

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