Temporal Multi-Omic Analysis Uncovers Sex-Biased Molecular Programs Underlying Skeletal Muscle Adaptation to Endurance Training
This work shows a large portion of the adaptive response to endurance training in skeletal muscle is shared between females and males, while there are distinct and nuanced sex-specific adaptations that are evident, particularly at the level of post-translational regulation.
Authors
- Christopher Jin (ORCID: https://orcid.org/0000-0001-7340-5023)
- Nicholas Day (ORCID: https://orcid.org/0000-0003-0291-436X)
- Qian Wei-jun
- C. F. Newgard
- Akshay Bareja (ORCID: https://orcid.org/0000-0001-9033-4116)
- David A. Gaul (ORCID: https://orcid.org/0000-0002-9308-1895)
- Andrea Lynn Hevener (ORCID: https://orcid.org/0000-0003-1508-4377)
- W. M. Kohrt
- William E. Kraus (ORCID: https://orcid.org/0000-0003-1930-9684)
- Isaac Attah (ORCID: https://orcid.org/0000-0002-9626-2069)
- Michael Snyder (ORCID: https://orcid.org/0000-0003-0784-7987)
- James Sanford (ORCID: https://orcid.org/0000-0001-7901-5579)
- Facundo M. Fernández (ORCID: https://orcid.org/0000-0002-0302-2534)
- Eric A. Ortlund (ORCID: https://orcid.org/0000-0001-8855-3029)
- Mark R. Viggars (ORCID: https://orcid.org/0000-0002-0722-7051)
- Kayleigh M. Voos (ORCID: https://orcid.org/0000-0002-2857-9515)
- Kim M. Huffman (ORCID: https://orcid.org/0000-0003-4708-4734)
- Hugh Mitchell (ORCID: https://orcid.org/0000-0003-0143-8461)
- Maléne E. Lindholm (ORCID: https://orcid.org/0000-0002-5763-7833)
- Gayatri Iyer (ORCID: https://orcid.org/0000-0002-8100-0832)
- Tyler J. Sagendorf (ORCID: https://orcid.org/0000-0003-1552-4870)
- Gergory Smith
- Xiaolu Li (ORCID: https://orcid.org/0000-0002-9845-1584)
- Gina M. Many (ORCID: https://orcid.org/0000-0003-4779-1690)
- Matthew Gaffrey
- Joshua Adkins (ORCID: https://orcid.org/0000-0003-0399-0700)
- David Jimenez-Morales
- Damon T. A Leach
- Karyn A. Esser
- Simon Schenk
- Sue C Bodine
- the MoTrPAC study group
- Charles F. Burant
Institutions
- Joslin Diabetes Center (US)
- Georgia Institute of Technology (US)
- Pacific Northwest National Laboratory (US)
- Emory University (US)
- Duke University (US)
- University of Michigan (US)
- UCLA Health (US)
- Oklahoma Medical Research Foundation (US)
- University of Florida (US)
- University of California San Diego (US)
- Duke Medical Center (US)
- University of Colorado Anschutz Medical Campus (US)
- Stanford University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-27
- DOI
- https://doi.org/10.64898/2025.12.26.696612
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health