Tumor CTR1 and serum copper dynamics reveal a coordinated copper axis linked to high-grade triple-negative breast cancer biology
Parallel CTR1 upregulation in tumors and systemic copper elevation post-therapy suggest a coordinated copper mobilization program in high-grade TNBC. These integrated retrospective and prospective findings link copper transport to therapy response and tumor aggressiveness, highlighting copper biology as a potential therapeutic axis in breast cancer.
Authors
- Vinit Shanbhag (ORCID: https://orcid.org/0000-0002-6188-7421)
- Christos Papageorgiou (ORCID: https://orcid.org/0000-0003-4105-098X)
- Linda T. Vahdat (ORCID: https://orcid.org/0000-0002-3522-7382)
- Praveen Rao (ORCID: https://orcid.org/0000-0003-3199-7803)
- Nikita Gudekar
- Michael Petris
- Kristyn Conrad
- Samuel Anakpeba-Dinguyella
- Muhammad Yasir
Institutions
- Dartmouth–Hitchcock Medical Center (US)
- University of Missouri Health System (US)
- University of Missouri (US)
Publication Details
- Journal
- medRxiv
- Published
- 2025-12-27
- DOI
- https://doi.org/10.64898/2025.12.18.25342516
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00