Pin1 as a Central Modulator of Wnt/β-Catenin Signaling in Pulmonary Fibrosis: Interplay with EBV-LMP1 and Therapeutic Implications

Pin1 is a critical regulator of the Wnt/β-catenin pathway in PF, integrating signals from viral and cellular modulators. This study provides novel evidence of EBV-LMP1's role in activating Pin1 in lung fibroblasts, reinforcing its value as a therapeutic target. Pin1 inhibitors effectively downregulate this signaling cascade, even under hyperactive conditions, highlighting their therapeutic potential for PF treatment. While Pin1 inhibitors effectively downregulate this signaling cascade even under hyperactive conditions, their therapeutic potential remains to be validated in preclinical models.