Neuronal Sorbs2 Regulates Learning And Memory Through Multiple Mechanisms
Our results suggest Sorbs2 regulates MT stability and alternative splicing in neurons and is involved in memory formation or retrieval. We have generated custom antibodies and RNAscope probes that identify Sorbs2-expressing cell populations in the brain, investigate Sorbs2 isoform expression, and assess the intersection between Sorbs2 and AD phenotypes in mouse models of neurodegeneration.
Authors
- Jared M. McLendon (ORCID: https://orcid.org/0000-0002-1002-5872)
- Henry C. Lin (ORCID: https://orcid.org/0000-0002-1263-5404)
- Ryan L. Boudreau (ORCID: https://orcid.org/0000-0002-9800-5349)
- Kailey Said
- Grace Rocco
Institutions
- University of Iowa (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107563
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00