Deposition patterns of proteinopathies in medial temporal lobe subregions: implications for neuroimaging
While p-tau, TDP-43, and argyrophilic grain proteinopathies show similar deposition patterns across MTL subregions, other proteinopathies showed selective vulnerability to more unique MTL subregions. The identified deposition patterns may inform patterns of downstream neurodegeneration and guide the development of sensitive and specific imaging biomarkers across these heterogeneous proteinopathies.
Authors
- Daniel T. Ohm (ORCID: https://orcid.org/0000-0002-7930-5434)
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Anika Wuestefeld (ORCID: https://orcid.org/0000-0003-1779-3388)
- Maud M.A. Bouwman (ORCID: https://orcid.org/0000-0002-9481-0332)
- Alex J. Wesseling
- Laura Jonkman
- Laura E.M. Wisse
- Paul A. Yushkevich
- Hannah Tucker
Institutions
- Lund University (SE)
- Penn Center for AIDS Research (US)
- Amsterdam University Medical Centers (NL)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_098998
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00