Inhibitors of KAT2A Alleviate the Progression of AKI by Alleviating Macrophage Ferritinophagy

These findings demonstrate that KAT2A promotes AKI progression via NCOA4-mediated ferritinophagy and cGAS-STING inflammatory signaling in macrophages, highlighting KAT2A inhibition as a promising therapeutic strategy for AKI.

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Publication Details

Journal
ImmunoTargets and Therapy
Published
2025-12-01
DOI
https://doi.org/10.2147/itt.s568586
Primary Topic
interferon and immune responses
Type
article
Field-Weighted Citation Impact
0.00
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article

Inhibitors of KAT2A Alleviate the Progression of AKI by Alleviating Macrophage Ferritinophagy

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ImmunoTargets and Therapy
interferon and immune responses
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Inhibitors of KAT2A Alleviate the Progression of AKI by Alleviating Macrophage Ferritinophagy

ShengLan Gao, Lawei Yang, Zhenying Zuo, Jiaxuan Chen, Qingjun Pan, Hongluan Wu, Huafeng Liu, Chen Yang, Zhiliang Lu, Zhongyu Liu, Jinzheng Wang, Xiaorong Hang
article en

Abstract

These findings demonstrate that KAT2A promotes AKI progression via NCOA4-mediated ferritinophagy and cGAS-STING inflammatory signaling in macrophages, highlighting KAT2A inhibition as a promising therapeutic strategy for AKI.

ImmunoTargets and TherapyVol. Volume 14
Guangdong Medical College (CN)
Zero hunger
Openalex Percentile: Top 36%
interferon and immune responses
DOIOpen Access PDFOpenAlex
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