Development and Evaluation of Biocompatible Scaffolds for Chronic Wound Healing and Biomaterials: Incorporating Vancomycin and Graphene Oxide

Chronic wounds represent a considerable challenge for healthcare systems, necessitating the identification of effective wound dressings to facilitate healing. This study aimed to develop scaffolds utilizing biocompatible materials such as albumin and gelatin, with the incorporation of vancomycin for its antibacterial properties and graphene oxide nanoparticles to enhance mechanical strength. The scaffolds were fabricated through a freeze-drying technique and subsequently evaluated for morphology using scanning electron microscopy (SEM), functional groups via Fourier-transform infrared spectroscopy (FTIR), and assessed for swelling, biodegradability, along with various mechanical, biological, and antibacterial properties. The release profile of vancomycin from the G.5%Al.3%Go scaffold exhibited a more controlled pattern compared to that of the G.5%Al.1%Go scaffold. Additionally, immersion of the scaffolds in phosphate-buffered saline for 30 minutes indicated that increased graphene oxide content correlated with reduced swelling. Over a 15-day period, the degradation rate of the scaffolds revealed that the G.10%Al.3%Go scaffold degraded by up to 35%, while the G.5%Al.1%Go scaffold showed the lowest degradation rate at 18%. These results shows that the G.10%Al.3%Go scaffold may serve as a promising candidate for atopic treatment.