Stemness factor Mex3a times translation and protein trafficking to ensure robust differentiation of olfactory sensory neurons
Loss of stemness factor Mex3a in immature olfactory neurons leads to defects in mature olfactory neurons.Translation/Trafficking of cell surface proteins, cilia structure, and planar cell polarity are compromised in the absence of Mex3a.Mex3a may confer K27 ubiquitination on stress granule protein Serbp1 and ribosome protein Rps7.Mex3a levels are associated with Serbp1 and p-eEF2 recruitment to ribosomes.
Authors
- Lauren C. Tang (ORCID: https://orcid.org/0000-0001-8786-5418)
- Rachel Duffié (ORCID: https://orcid.org/0000-0001-8529-1377)
- Joan Pulupa (ORCID: https://orcid.org/0000-0003-3858-1886)
- Albana Kodra (ORCID: https://orcid.org/0000-0003-4267-3679)
- Adan Horta
- Junqiang Ye (ORCID: https://orcid.org/0000-0002-4529-0713)
- Hani Shayya (ORCID: https://orcid.org/0000-0002-0041-1956)
- Abdurrahman Keskin (ORCID: https://orcid.org/0000-0002-5016-6864)
- Marko Jovanović (ORCID: https://orcid.org/0000-0001-9707-3377)
- Stavros Lomvardas (ORCID: https://orcid.org/0000-0002-7668-3026)
- Olga Stathi
- Aileen Ugurbil
- Martin Escamilla-del-Arenal
Institutions
- MIND Research Institute (US)
- Columbia University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-27
- DOI
- https://doi.org/10.64898/2025.12.26.696633
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00