Toxoplasma gondii-induced ferroptosis contributes to acute lung injury in mice
Our findings revealed that T. gondii infection triggered ferroptosis by compromising dysregulated iron metabolism and antioxidant defenses, playing a key role in T. gondii-induced lung injury. DFP exhibited a promising therapy effect for toxoplasmosis.
Authors
- Penglin Bao
- Xiaocen WANG
- Feixue Liu
- Yeting Ma
- Boya Du (ORCID: https://orcid.org/0000-0002-7593-6335)
- Xun Yuan (ORCID: https://orcid.org/0000-0001-6843-6466)
- Pengtao Gong
- Jianhua Li
- Xu Zhang
- Nan Zhang
- Zhenzhen Liu
- Xin Li
Institutions
- Jilin University (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-12-28
- DOI
- https://doi.org/10.1186/s13071-025-07207-x
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04