Plasma proteomics mediate the association between degenerative joint diseases and dementia risk
DJDs are independently associated with an increased risk of developing dementia. This correlation is mediated by systemic proteomic alterations. Our findings highlight inflammation and vascular dysfunction as central mechanisms, offering insights into risk stratification and therapeutic targets for preventing dementia.
Authors
- Edward C.H. Lau
- Shengming Dai (ORCID: https://orcid.org/0000-0001-7398-3165)
- Jianzheng Zhang (ORCID: https://orcid.org/0000-0003-3996-6198)
- Ying Zhu
- Ping Li
- Kai Li
- Zijian Kang
- Qiang Tong
- Chen Zhu
Institutions
- Donghua University (CN)
- Shanghai Jiao Tong University (CN)
- Queen Mary Hospital (CN)
- Chinese PLA General Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- China Agricultural University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jare.2025.12.044
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16