Temporal molecular remodeling of T cells informs their possible adaptation in 4T1 tumors
The temporally coordinated immune shifts, such as progressive decline in transcripts associated with T cell functions, TCRs, APCs, and sustained macrophage-driven immunosuppression, suggest tumor-driven adaptation toward immune evasion and identify potential windows for stage-specific immunotherapeutic intervention.
Authors
- Misty D. Thomas (ORCID: https://orcid.org/0000-0001-9039-4098)
- Perpetua M. Muganda (ORCID: https://orcid.org/0000-0001-5928-6822)
- Scott H. Harrison (ORCID: https://orcid.org/0000-0002-9577-445X)
- Joseph L. Graves (ORCID: https://orcid.org/0000-0001-8446-1709)
- Roshonda B. Jones (ORCID: https://orcid.org/0000-0003-1637-3517)
- M. Hossain
- Dipongkor Saha (ORCID: https://orcid.org/0000-0002-9923-5533)
- Checo J. Rorie (ORCID: https://orcid.org/0000-0002-7130-6790)
- Bryan L. Holloman (ORCID: https://orcid.org/0000-0002-9891-9001)
- Howard L. Kaufman
- Md. Iftehimul
- Robert H. Newman
Institutions
- Massachusetts Eye and Ear Infirmary (US)
- Bangladesh Agricultural University (BD)
- North Carolina Agricultural and Technical State University (US)
Publication Details
- Journal
- Computational and Structural Biotechnology Journal
- Published
- 2025-12-28
- DOI
- https://doi.org/10.1016/j.csbj.2025.12.022
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00