Reducing the overall use of broad-spectrum antibiotics in NICU is associated with less prevalence of multi-drug resistant Klebsiella pneumoniae isolation in premature infants

This study demonstrates that reducing broad-spectrum antibiotic use in NICUs may lower the prevalence of MDR K. pneumoniae colonization and infection in premature infants.

Authors

Mingjie Wang (ORCID: https://orcid.org/0000-0002-5680-2390)
Yi Liu (ORCID: https://orcid.org/0000-0002-1058-0382)
Jing S. Lin
Shaojie Yue
Ying Ding
Meiyan Chu
Chuanding Cao
Zhengchang Liao

Institutions

Central South University (CN)
Xiangya Hospital Central South University (CN)
Icahn School of Medicine at Mount Sinai (US)

Publication Details

Journal: Antimicrobial Resistance and Infection Control
Published: 2025-12-28
DOI: https://doi.org/10.1186/s13756-025-01693-5
Primary Topic: Neonatal and Maternal Infections
Type: article
Field-Weighted Citation Impact: 0.00

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article

Reducing the overall use of broad-spectrum antibiotics in NICU is associated with less prevalence of multi-drug resistant Klebsiella pneumoniae isolation in premature infants

Mingjie Wang, Yi Liu, Jing S. Lin, Shaojie Yue et al.

Dec 28, 2025

Antimicrobial Resistance and Infection Control

Neonatal and Maternal Infections

article

Reducing the overall use of broad-spectrum antibiotics in NICU is associated with less prevalence of multi-drug resistant Klebsiella pneumoniae isolation in premature infants

Mingjie Wang, Yi Liu, Jing S. Lin, Shaojie Yue, Ying Ding, Meiyan Chu, Chuanding Cao, Zhengchang Liao

December 28, 2025article en

Abstract

This study demonstrates that reducing broad-spectrum antibiotic use in NICUs may lower the prevalence of MDR K. pneumoniae colonization and infection in premature infants.

Antimicrobial Resistance and Infection ControlVol. 15(1)

Central South University (CN), Xiangya Hospital Central South University (CN), Icahn School of Medicine at Mount Sinai (US)

Good health and well-being

Openalex Percentile: Top 26%

Neonatal and Maternal Infections

DOI Open Access PDF OpenAlex

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Reducing the overall use of broad-spectrum antibiotics in NICU is associated with less prevalence of multi-drug resistant Klebsiella pneumoniae isolation in premature infants — Mingjie Wang, Yi Liu, et al. · Antimicrobial Resistance and Infection Control (2025) | TGRS Research Map | TGRS