Real-World Data on Barrigel and SpaceOAR Rectal Spacers in Prostate Cancer Radiation Therapy: A Comparative Analysis

Real-world data show that SpaceOAR achieves better dosimetry than Barrigel likely due to larger insertion volumes. At similar insertion volumes, Barrigel achieves lower irradiated rectal volumes compared to SpaceOAR. Dosimetric outcomes are more likely impacted by volume rather than symmetry of insertion. The SQS scoring method may have better utility than the FV scoring method for assessing dosimetric outcomes. Our data also indicate that Barrigel has a lower incidence of rectal wall infiltration compared with SpaceOAR.