Sex Differences in the role of Additive Genetic Variants in Autism: A Systematic Review
Findings suggest an axis of heterogeneity around intellectual disability. Inconsistent findings largely resulted in inconclusive evidence. Results highlight a lack of sex-stratified reporting and were limited by sample makeup such as male- and European ancestry dominated cohorts. Future sex-balanced and stratified GWAS and downstream analyses with complete reporting of female and male data are needed to clarify potential genetic sex differences in autism.
Authors
- Wonuola A. Akingbuwa (ORCID: https://orcid.org/0000-0002-8205-0807)
- Aleksandra Badura (ORCID: https://orcid.org/0000-0001-7109-572X)
- Tinca J. C. Polderman (ORCID: https://orcid.org/0000-0001-5564-301X)
- Thomas Sollie
- M. van Milligen de Wit
Institutions
- Erasmus MC (NL)
- GGD Amsterdam (NL)
- Vrije Universiteit Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- medRxiv
- Published
- 2025-12-27
- DOI
- https://doi.org/10.64898/2025.12.23.25342905
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- National Institutes of Health
- National Institute of Mental Health