Motor response in monogenic LRRK2 parkinson's disease after deep brain stimulation: A systematic review and meta-analysis.

LRRK2 PD exhibited diverse motor outcomes depending on the specific mutation variant when subjected to DBS. Patients with LRRK2 variants G2019S and G2385R demonstrated clinically significant improvements in motor responses, while those with the R1441G variant showed inadequate motor response.

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PubMed
Published
2025-12-01
Primary Topic
Neurological disorders and treatments
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article
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article

Motor response in monogenic LRRK2 parkinson's disease after deep brain stimulation: A systematic review and meta-analysis.

A. Gofir, Subagya Subagya, Ismail Setyopranoto, S Wibowo et al.
PubMed
Neurological disorders and treatments
article

Motor response in monogenic LRRK2 parkinson's disease after deep brain stimulation: A systematic review and meta-analysis.

A. Gofir, Subagya Subagya, Ismail Setyopranoto, S Wibowo, M Ar Rochmah, D B Nugroho, D P Wibisono
article en

Abstract

LRRK2 PD exhibited diverse motor outcomes depending on the specific mutation variant when subjected to DBS. Patients with LRRK2 variants G2019S and G2385R demonstrated clinically significant improvements in motor responses, while those with the R1441G variant showed inadequate motor response.

PubMedVol. 80(Suppl 7)
Universitas Gadjah Mada (ID)
Good health and well-being
Openalex Percentile: Top 30%
Neurological disorders and treatments
OpenAlex
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Motor response in monogenic LRRK2 parkinson's disease after deep brain stimulation: A systematic review and meta-analysis. — A. Gofir, Subagya Subagya, et al. · PubMed (2025) | TGRS Research Map | TGRS