Diagnostic accuracy of perineural invasion in oral squamous cell carcinoma is improved by immunohistochemistry and correlates with locoregional recurrence
S100 immunohistochemistry is useful to improve the diagnostic accuracy of PNI in OSCC by reducing the alpha and beta errors. PNI is common in OSCC, and PNI S100 diagnosis correlates with locoregional OSCC recurrence. High cell proliferation (Ki-67) was useful in predicting lymph node metastasis.
Authors
- Alexandre Augusto Sarto Dominguette (ORCID: https://orcid.org/0000-0002-3346-0586)
- Bruno Henrique Figueiredo Matos (ORCID: https://orcid.org/0009-0003-6717-1541)
- Maria Clara Avila de Oliveira (ORCID: https://orcid.org/0000-0002-4381-3103)
- Cleyton Andrade
- Ana Claudia Couto de Abreu
Institutions
- University of Caldas (CO)
- Systems Analytics (United States) (US)
- Universidade Vale do Rio Verde (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Journal of Oral and Maxillofacial Pathology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.4103/jomfp.jomfp_34_25
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00