Spatial and single-cell transcriptomics landscape of adenomyosis
Our findings provide evidence for the invagination theory, highlighting the involvement of ciliated epithelial cells and immune-angiogenic crosstalk in adenomyosis pathogenesis. Moreover, this study demonstrates that GnRHa exerts therapeutic effects through the normalization of immune cell composition and restoration of epithelial-stromal interaction, offering novel mechanistic insights into its mode of action.
Authors
- Shengbao Suo (ORCID: https://orcid.org/0009-0008-8943-2956)
- Chuanchuan Zhou (ORCID: https://orcid.org/0000-0003-1535-4509)
- Zhi Zeng
- Guizhong Cui (ORCID: https://orcid.org/0000-0001-6394-2773)
- Guangdun Peng
- Manchao Li (ORCID: https://orcid.org/0000-0003-0492-9389)
- Linyan Lv
- Xiaoyan Liang
- Xing Yang
- Jian Xu
- Chunjie Li
- Yuan Lin
- Bingbing Xie
- Shuqin Chen
- Junxian He
- Guihua Liu
- Jinfeng Tan
Institutions
- Sun Yat-sen University (CN)
- Guangzhou Institutes of Biomedicine and Health (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- University of Hong Kong (HK)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jare.2025.12.042
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00