Sertraline-Induced Lipase-Sparing Acute Interstitial Edematous Pancreatitis: A Case Report

Abstract Sertraline, a selective serotonin reuptake inhibitor (SSRI), has been associated with rare cases of acute pancreatitis. We report a case of sertraline-induced, lipase-sparing acute interstitial edematous pancreatitis in a young professional, initially misdiagnosed as acute cholecystitis. On rechallenge, the patient developed recurrent symptoms with elevated inflammatory markers but normal ultrasound findings. Contrast-enhanced computed tomography confirmed acute interstitial edematous pancreatitis with associated venous thrombosis. Withdrawal of sertraline and substitution with an alternative antidepressant led to complete resolution. This case highlights the diagnostic challenge of lipase-sparing pancreatitis and underscores the importance of considering drug-induced etiologies.