Serum GFAP as a biomarker for progression in multiple sclerosis: assay comparison and a large reference database of healthy controls
Serum GFAP measured by Elecsys shows a comparable association with time-to-PIRA as Simoa, and GFAP<sub>Simoa</sub> Z scores can be successfully bridged to GFAP<sub>Elecsys</sub> Z scores, supporting Elecsys`s potential for clinical implementation.
Authors
- Nafiye Genc
- Patrice H. Lalive (ORCID: https://orcid.org/0000-0003-0607-5778)
- C. Pot
- Sofia Sandgren (ORCID: https://orcid.org/0000-0001-6206-3339)
- Marina Herwerth (ORCID: https://orcid.org/0000-0001-5125-4594)
- Giulio Disanto (ORCID: https://orcid.org/0000-0002-8512-6096)
- Chiara Zecca (ORCID: https://orcid.org/0000-0002-9990-3431)
- Marco Hermesdorf (ORCID: https://orcid.org/0000-0003-3541-7212)
- P. Roth
- Sebastian Finkener (ORCID: https://orcid.org/0000-0001-6449-0756)
- Aleksandra Maleska Maceski (ORCID: https://orcid.org/0000-0002-1916-5927)
- Johanna Oechtering (ORCID: https://orcid.org/0000-0001-5359-7961)
- Klaus Berger
- Marcus D’Souza
- Stefanie Müller
- Amar Zadic
- Robert Hoepner
- Jens Kuhle
- Claudio Gobbi
- Maximilian Einsiedler
- Eline A.J. Willemse
- Cristina Granziera
- Sabine Schaedelin
- David Leppert
- Pascal Benkert
- Juan F. Vilchez Gomez
Institutions
- University of Geneva (CH)
- University of St.Gallen (CH)
- University of Münster (DE)
- University Hospital of Bern (CH)
- Centre Hospitalier Universitaire Vaudois (CH)
- University Hospital of Basel (CH)
- Laboratory for Biomedical Neurosciences (CH)
- Ente Ospedaliero Cantonale (CH)
- University Hospital of Zurich (CH)
- University Hospital of Geneva (CH)
- Department of Biomedicine Basel (CH)
- Kantonsspital Aarau (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1515/cclm-2025-1480
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00