Expanding the spectrum of AFF2 undifferentiated sarcoma associated to endometriosis: a novel ZDHHC9::AFF2 fusion sarcoma with high-grade features and poor prognosis
In conclusion, this case expands the morphological spectrum of <i>AFF2</i>-related sarcomas, providing further evidence of their pathological heterogeneity. Moreover, it identifies a novel fusion, which may have implications for tumor classification and diagnostic refinement. The morphological findings also suggest a possible association with poor clinical outcomes.
Authors
- Rita Alaggio (ORCID: https://orcid.org/0000-0003-3915-3816)
- Sara Patrizi (ORCID: https://orcid.org/0000-0003-3133-8015)
- Damiano Arciuolo (ORCID: https://orcid.org/0000-0002-3927-985X)
- Frediano Inzani (ORCID: https://orcid.org/0000-0002-9061-6989)
- Giulia Scaglione (ORCID: https://orcid.org/0000-0002-9060-3854)
- Antonio Travaglino (ORCID: https://orcid.org/0000-0003-4002-1618)
- A Santoro
- Evelina Miele
- Isabella Giovannoni
- Sabina Barresi
- Gian Franco Zannoni
- Luigi Pedone Anchora
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Insubria (IT)
- University of Pavia (IT)
- Agostino Gemelli University Polyclinic (IT)
- Bambino Gesù Children's Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Pathologica
- Published
- 2025-12-01
- DOI
- https://doi.org/10.32074/1591-951x-1221
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00