Microstructural profiling and habitat analysis to characterize treatment outcome patterns in Sacral Chordomas treated with carbon ions
This study demonstrates the potential of DW-MRI-derived microstructural parameters and habitat imaging to capture intratumoral heterogeneity, assess treatment-induced microstructural changes, and identify high-risk patterns associated with LR in SC patients treated with CIRT. These findings support the integration of microstructural and habitat-based imaging as a non-invasive tool for risk stratification and personalized treatment planning in CIRT for SC.
Authors
- Silvia Molinelli (ORCID: https://orcid.org/0000-0002-5548-3949)
- Chiara Paganelli (ORCID: https://orcid.org/0000-0003-4787-8649)
- Marco Rotondi (ORCID: https://orcid.org/0000-0001-7730-9776)
- E. Orlandi
- Agnieszka Chalaszczyk (ORCID: https://orcid.org/0000-0003-4881-2422)
- Giuseppe Magro (ORCID: https://orcid.org/0000-0001-7140-8642)
- Sara Imparato (ORCID: https://orcid.org/0000-0001-6122-5877)
- Letizia Morelli (ORCID: https://orcid.org/0000-0002-5695-1767)
- Maria Rosaria Fiore
- Guido Baroni
- Giovanni Parrella
Institutions
- University of Pavia (IT)
- National Center for Oncological Hadrontherapy (IT)
- Politecnico di Milano (IT)
Publication Details
- Journal
- Medical Physics
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1002/mp.70208
- Primary Topic
- Bone Tumor Diagnosis and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00