Large rectal Tubulovillous adenoma leading to McKittrick–Wheelock syndrome

McKittrick-Wheelock syndrome (MWS) is a rare condition characterized by chronic diarrhea caused by colorectal villous adenoma, which can lead to severe hyponatremia, hypokalemia, and kidney injury. We present a case of MWS resulting from a 9.6 cm rectal tubulovillous adenoma, which caused significant electrolyte abnormalities and kidney injury. While MWS has been documented in association with villous adenomas, there is limited literature on its occurrence with tubulovillous adenomas, as seen in our case.