Dickkopf-related protein 2 impairs neurovascular Wnt signalling and worsens stroke outcome
Dickkopf-related protein 2 plays a critical role in the progression of ischaemic stroke by modulating neuronal survival and BBB integrity. Targeting DKK2 represents a promising therapeutic approach to ischaemic brain injury, and the observational human data extend experimental findings to human cerebrovascular pathology, suggesting translational potential.
Authors
- K.-H. Huang
- Ziying Feng
- Jinrui Li (ORCID: https://orcid.org/0009-0007-7318-3820)
- Yuzhi Ma (ORCID: https://orcid.org/0000-0001-8938-4829)
- Jianfeng Liu (ORCID: https://orcid.org/0000-0003-0541-5072)
- Zhu Shi
- JunLei Chang
- Cheng Fang (ORCID: https://orcid.org/0009-0003-3545-0116)
- Linhui Qiu
- Yanru Wang (ORCID: https://orcid.org/0000-0001-8272-2450)
- Z N Guo
- Yi Yang
- Feng Wang
Institutions
- Jilin University (CN)
- Dongguan People’s Hospital (CN)
- First Hospital of Jilin University (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- University of Chinese Academy of Sciences (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1093/eurheartj/ehaf959
- Citations
- 1
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81