Rising U.S. trends in HPV-positive and HPV-negative vulvar cancer in older adults, 2000–2020

The rising incidence of both HPV-positive and HPV-negative vulvar cancer among individuals aged ≥55 reflects shifting trends in disease burden. These findings align with prior SEER analyses showing an in situ diagnoses decline and a rise in invasive cases. In the absence of standardized screening guidelines for vulvar cancer, our results underscore the importance of continued surveillance and risk-based gynecologic evaluation strategies in older populations.

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Publication Details

Journal
Gynecologic Oncology Reports
Published
2025-12-27
DOI
https://doi.org/10.1016/j.gore.2025.102016
Primary Topic
Cervical Cancer and HPV Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Rising U.S. trends in HPV-positive and HPV-negative vulvar cancer in older adults, 2000–2020

Theodore Strange, Lohitha Dhulipalla, Mario Castellanos, Kathleen H. Scarbrough et al.
Gynecologic Oncology Reports
Cervical Cancer and HPV Research
article

Rising U.S. trends in HPV-positive and HPV-negative vulvar cancer in older adults, 2000–2020

Theodore Strange, Lohitha Dhulipalla, Mario Castellanos, Kathleen H. Scarbrough, Adi Davidov, Sritha Rajupet, Ana Paola Mata Zetina, Thomas Gut, Meekoo Dhar
article en

Abstract

The rising incidence of both HPV-positive and HPV-negative vulvar cancer among individuals aged ≥55 reflects shifting trends in disease burden. These findings align with prior SEER analyses showing an in situ diagnoses decline and a rise in invasive cases. In the absence of standardized screening guidelines for vulvar cancer, our results underscore the importance of continued surveillance and risk-based gynecologic evaluation strategies in older populations.

Gynecologic Oncology ReportsVol. 63
Philadelphia College of Osteopathic Medicine (US), Touro College (US), Staten Island University Hospital (US), Stony Brook School (US), Stony Brook University (US)
Good health and well-being
Openalex Percentile: Top 29%
Cervical Cancer and HPV Research
DOIOpen Access PDFOpenAlex
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Rising U.S. trends in HPV-positive and HPV-negative vulvar cancer in older adults, 2000–2020 — Theodore Strange, Lohitha Dhulipalla, et al. · Gynecologic Oncology Reports (2025) | TGRS Research Map | TGRS