Exploring the increasing aneuploidy stress effects on embryo morphokinetic development: non-linear and stage-specific disruption in developmental timing

These findings support a dosage-dependent model of developmental disruption, in which the severity and timing of morphokinetic delay correlate with aneuploidy complexity in a stage-specific and non-linear manner. While not diagnostic on their own, time-lapse imaging may contribute to ploidy risk assessment and help identify embryos that could benefit from biopsy and further evaluation through PGT-A, particularly when integrated with clinical, biomarker, and genomic information.