Prognostic impact of lymphocyte to monocyte ratio in patients with myelodysplastic neoplasms/syndromes
An elevated L/M ratio is an independent and readily available biomarker that predicts poor outcomes in MDS. Integration of this parameter into existing risk models may refine prognostication and guide treatment intensity. Transcriptomic findings suggest immune suppression and p53 deregulation underlie its adverse impact, highlighting potential therapeutic avenues.
Authors
- Hou Hsin-An
- Yuan Chang-Tsu
- Yao Chi-yuan
- M Y Liu
- Chou Wen-Chien
- Chien-Chin Lin
- Rwei‐Ling Yu (ORCID: https://orcid.org/0000-0001-5836-1237)
- Mei-Hsuan Tseng
- Yu-Sung Chang (ORCID: https://orcid.org/0009-0000-4571-3328)
- Hwei-Fang Tien
- Ming Yao
- Chia-Lang Hsu
- Wan-Hsuan Lee
- Feng-Ming Tien
- Yuan-Yeh Kuo
- Yen-Ling Peng
- Xavier Cheng-Hong Tsai (ORCID: https://orcid.org/0000-0002-4174-8766)
- Min-Yen Lo
- Bor-Sheng Ko
Institutions
- National Taiwan University (TW)
- Far Eastern Memorial Hospital (TW)
- National Taiwan University Hospital (TW)
- National Yunlin University of Science and Technology (TW)
- National Taipei University (TW)
Publication Details
- Journal
- Blood Research
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1007/s44313-025-00115-0
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00