Decoding epigenetic and transcriptional landscapes: DNA methylome-transcriptome integration reveals novel drivers in 4NQO-Induced esophageal squamous cell carcinoma mouse model
These findings highlight ESSH as a critical window where epigenetically driven immune changes facilitate ESCC progression. Targeting these early epigenetic-immune interactions may offer a novel strategy for ESCC early detection and combination therapy.
Authors
- Runhua Lin (ORCID: https://orcid.org/0000-0001-7014-9829)
- Yanli Qian
- Xinxin Zhang (ORCID: https://orcid.org/0000-0002-0598-6425)
- Zhiwei Liu
- Min Su
- Dongming Lin
Institutions
- Shantou University (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Shantou University Medical College (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1186/s13148-025-02035-3
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00