Development of a recombinant biosimilar single-chain variable fragment antibody targeting human estrogen receptor α36
The anti-ER-α36 scFv antibody fragment was successfully expressed using the <i>E. coli</i> expression system, and the purified protein was able to specifically recognize and bind to ER-α36-expressing human breast cancer cells.
Authors
- Sedighe Kolivand
- Soodabeh Shafiee (ORCID: https://orcid.org/0000-0001-7067-5140)
- Mohammad Abedini
- Mohadeseh Haji Abdolvahab
- Yeganeh Talebkhan
- Neda Jalili
- Mahboubeh Navabi
- Rezvan Esmaeili
Institutions
- Pasteur Institute of Iran (IR)
- Academic Center for Education, Culture and Research (IR)
- Biotechnology Research Center (IR)
- Motamed Cancer Institute (IR)
Publication Details
- Journal
- Research in Pharmaceutical Sciences
- Published
- 2025-12-26
- DOI
- https://doi.org/10.4103/rps.rps_131_25
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00