DNA methylation biomarkers as an early diagnostic tool in the progression of oral squamous cell carcinoma
Among the three genes studied, DAPK emerged as a reliable biomarker for early OSCC detection. The findings support its integration into methylation-based screening panels, while MGMT and p16 may serve as complementary markers. Further large-scale studies are recommended to validate their clinical utility.
Authors
- A Menon
- Sudheesh Manoharan (ORCID: https://orcid.org/0000-0003-2316-7578)
- Sethu Babu (ORCID: https://orcid.org/0000-0001-9259-5694)
- Bichu Jacob
- S. Sunil
- Yogesh Dalvi
Institutions
- Malabar Institute of Medical Sciences (IN)
- Malankara Orthodox Syrian Church Medical College Hospital (IN)
- Pushpagiri Medical College (IN)
- APJ Abdul Kalam Technological University (IN)
Publication Details
- Journal
- Journal of Oral and Maxillofacial Pathology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.4103/jomfp.jomfp_199_25
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00