Total‐body PET Amyloid Signal in the Liver in Alzheimer's Disease
Like the brain, separation of Aβ+ and Aβ- individuals over time occurred at later time points in the liver, suggesting 90-110 min is the optimal window for amyloid signal evaluation in the liver. Current work in progress is building upon these findings by using simultaneous total-body quantitative kinetic modeling in brain and liver to highlighting specific systemic molecular processes in AD.
Authors
- Emily Nicole Holy (ORCID: https://orcid.org/0009-0000-9420-9195)
- Audrey P. Fan (ORCID: https://orcid.org/0000-0001-5850-6117)
- Guobao B. Wang
- Benjamin A. Spencer
- Simon R. Cherry
- Charles Decarli
Institutions
- Alzheimer’s Disease Neuroimaging Initiative (US)
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104641
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00