EP300 confers protection against acute pancreatitis via acetylating HSF1 and promoting PRKN-mediated mitophagy in pancreatic acinar cells
These findings highlight the critical role of EP300 in regulating HSF1 acetylation and stability, which in turn modulates mitophagy and pyroptosis in AP. Targeting EP300 and its downstream pathways, such as HSF1-PRKN axis, may offer novel therapeutic strategies for AP.
Authors
- Ke Liu (ORCID: https://orcid.org/0000-0001-9411-4639)
- Heng Zhang (ORCID: https://orcid.org/0000-0002-0103-2173)
- Zehong Qi
- L-Y Zhu (ORCID: https://orcid.org/0000-0001-6988-0091)
- S N Tan
- Yuhang Fan
- Nian Wang
- Huan Chen
- Kangkai Wang
Institutions
- Central South University (CN)
- Hunan Cancer Hospital (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1186/s12964-025-02604-2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00