Pesco-Vegetarian Food Components Promote Colonocyte Ferroptosis in Preclinical Mouse Models and a Randomized Crossover Trial in Healthy Human Adults
Our findings demonstrate that dietary fish oil and fermentable fiber combination induces ferroptosis exclusively in colonocytes. The human pilot study was registered at clinicaltrials.gov as NCT04211766.
Authors
- Lisa Levy (ORCID: https://orcid.org/0009-0001-3367-4760)
- D. Mullens (ORCID: https://orcid.org/0000-0001-7379-6386)
- Robert S. Chapkin (ORCID: https://orcid.org/0000-0002-6515-3898)
- James J. Cai (ORCID: https://orcid.org/0000-0002-8081-6725)
- Meredith A.J. Hullar (ORCID: https://orcid.org/0000-0002-5322-9568)
- Laurie A. Davidson (ORCID: https://orcid.org/0000-0002-4159-4680)
- Sandi L. Navarro (ORCID: https://orcid.org/0000-0002-4260-2486)
- Jennifer S. Goldsby
- Arul Jayaraman
- Johanna W. Lampe
- Michael L. Salinas
- Yang-Yi Fan
- Ivan V. Ivanov
Institutions
- Fred Hutch Cancer Center (US)
- Texas A&M University (US)
Publication Details
- Journal
- Journal of Nutrition
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1016/j.tjnut.2025.101287
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00