Conditioned media and extracellular vesicles derived from human Wharton’s jelly mesenchymal stem cells improve the in vitro maturation of immature oocytes in normal and PCOS mouse model
These findings suggest that hWJMSC-derived secretomes, particularly CM, enhance oocyte maturation and quality, offering potential therapeutic benefits for IVM in both normal and PCOS conditions.
Authors
- Fatemeh Zal (ORCID: https://orcid.org/0000-0002-7078-4854)
- Mahintaj Dara (ORCID: https://orcid.org/0000-0003-0087-3162)
- Arezoo Solati
- Shayesteh Mehdinejadiani (ORCID: https://orcid.org/0000-0002-7905-8314)
- Sedigheh Bahmyari (ORCID: https://orcid.org/0000-0002-6987-5919)
- Z Khodabandeh
- Sanaz Alaee
Institutions
- Royal Netherlands Academy of Arts and Sciences (NL)
- University of Calgary (CA)
- Shiraz University of Medical Sciences (IR)
- Khalili Hospital (IR)
Publication Details
- Journal
- BioMedical Engineering OnLine
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1186/s12938-025-01500-7
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00