FABP4‐mediated lipid droplet accumulation drives epithelial–mesenchymal transition and aggravates alveolar epithelial barrier disruption
LIRI induces autocrine FABP4 signaling in alveolar epithelial cells. FABP4 promotes lipid droplets accumulation by inhibiting lipophagy through p38 MAPKULK1 signaling. FABP4-driven lipid metabolic reprogramming triggers EMT and disrupts alveolar epithelial barrier integrity. Targeting FABP4 or lipid droplets accumulation may offer therapeutic potential for CPB-associated ARDS.
Authors
- Min Wu (ORCID: https://orcid.org/0000-0003-4415-0273)
- Mingyu Chu
- Linjie Si (ORCID: https://orcid.org/0000-0002-1523-5369)
- X. T. Li
- Jialin Zhang (ORCID: https://orcid.org/0009-0005-6656-7047)
- Ye Wang (ORCID: https://orcid.org/0000-0003-1963-5105)
- Xiaoning Lu
- Peng Lü (ORCID: https://orcid.org/0000-0002-2259-2700)
- Zihao Shen
- Z. Liu (ORCID: https://orcid.org/0009-0000-4687-1571)
- Yuanpu Qi
- Chen Feng
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1002/ctm2.70563
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00