CEST MRI assessment of HIV-1-associated neurometabolic impairments in a humanized mouse model
CEST MRI detects region-specific metabolic abnormalities during HIV-1 infection and region-specific metabolic recovery with ART, consistent with reduced viral burden and neuroinflammation. These findings support CEST MRI as a promising non-invasive biomarker for monitoring treatment response and disease progression in neuroHIV.
Authors
- Martina Thiele
- Aditya N. Bade (ORCID: https://orcid.org/0000-0003-2511-4461)
- Emma G. Foster (ORCID: https://orcid.org/0000-0003-1241-1918)
- Y. Liu
- Santhi Gorantla (ORCID: https://orcid.org/0000-0002-9064-1084)
- Mariano Uberti (ORCID: https://orcid.org/0000-0002-7535-3682)
- Manjeet Kumar (ORCID: https://orcid.org/0000-0001-5355-9041)
- Gabriel C. Gauthier
- Micah Summerlin
- Balasrinivasa R. Sajja
Institutions
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- NeuroImmune Pharmacology and Therapeutics
- Published
- 2025-12-27
- DOI
- https://doi.org/10.1515/nipt-2025-0017
- Primary Topic
- Lanthanide and Transition Metal Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.00