A Novel <scp>MPT</scp> ‐Driven Necrosis‐Related <scp>lncRNA</scp> Signature for Prognostic Prediction in Hepatocellular Carcinoma: Validation Using Organoids
The effective construction of an MPT-driven necrosis-related prognostic model highlights its potential to independently predict the prognosis of patients with HCC. These findings not only deepen our understanding of MPT-driven necrosis but also offer novel theoretical foundations for developing more effective treatment strategies. The gene LINC02313 has been identified as a promoter of HCC's ability to proliferate and invade, underscoring its potential as a therapeutic target for HCC.
Authors
- Liye Tao
- Shihao Li (ORCID: https://orcid.org/0000-0002-8479-763X)
- Zheng Jiao
- Hongjun Chen (ORCID: https://orcid.org/0000-0001-9326-9188)
- Jingwei Cai
- Yu Liu (ORCID: https://orcid.org/0009-0003-7020-7832)
- Yu Xie
- Haoyu Pan
- Yanru Wang (ORCID: https://orcid.org/0000-0001-8272-2450)
- Xiao Liang
- Zefeng Shen
- Junjie Xu
- Meijie Chen
- Renan Jin
Institutions
- Zhejiang Chinese Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- Center for Special Minimally Invasive and Robotic Surgery (US)
- Hangzhou Medical College (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1002/cam4.71445
- Citations
- 1
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- National Natural Science Foundation of China
- Science and Technology Department of Zhejiang Province
- Science and Technology Program of Zhejiang Province