The Hill–Langmuir Equation Governs Drug–Target Binding Kinetics for Pulsed Drug Delivery

When designing pulsed drug delivery, the elimination rate constant must be greater than the dose frequency. The association rate constant produces a fast effect, whereas the dissociation rate constant produces a slow but sustained effect.

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Publication Details

Journal
Fundamental and Clinical Pharmacology
Published
2025-12-27
DOI
https://doi.org/10.1111/fcp.70069
Primary Topic
Receptor Mechanisms and Signaling
Type
article
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article

The Hill–Langmuir Equation Governs Drug–Target Binding Kinetics for Pulsed Drug Delivery

X. Q. Shi
Fundamental and Clinical Pharmacology
Receptor Mechanisms and Signaling
article

The Hill–Langmuir Equation Governs Drug–Target Binding Kinetics for Pulsed Drug Delivery

X. Q. Shi
article en

Abstract

When designing pulsed drug delivery, the elimination rate constant must be greater than the dose frequency. The association rate constant produces a fast effect, whereas the dissociation rate constant produces a slow but sustained effect.

Fundamental and Clinical PharmacologyVol. 40(1)
Shanghai University (CN)
Good health and well-being
Openalex Percentile: Top 36%
Receptor Mechanisms and Signaling
DOISourceOpenAlex
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The Hill–Langmuir Equation Governs Drug–Target Binding Kinetics for Pulsed Drug Delivery — X. Q. Shi · Fundamental and Clinical Pharmacology (2025) | TGRS Research Map | TGRS