Immunometabolism of T cells and macrophages: Human translational perspectives

Human immunometabolism is defined by dynamic substrate switching. Targeting glycolysis, FAO, or tryptophan metabolism offers therapeutic leverage in cancer and autoimmune disease. Future directions include single-cell and spatial metabolomics and integrative metabolic-immune modeling.

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Publication Details

Journal
Immunobiology
Published
2025-12-27
DOI
https://doi.org/10.1016/j.imbio.2025.153151
Primary Topic
Immune cells in cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

Immunometabolism of T cells and macrophages: Human translational perspectives

Borros Michael Arneth
Immunobiology
Immune cells in cancer
article

Immunometabolism of T cells and macrophages: Human translational perspectives

Borros Michael Arneth
article en

Abstract

Human immunometabolism is defined by dynamic substrate switching. Targeting glycolysis, FAO, or tryptophan metabolism offers therapeutic leverage in cancer and autoimmune disease. Future directions include single-cell and spatial metabolomics and integrative metabolic-immune modeling.

ImmunobiologyVol. 231(1)
Universitätsklinikum Gießen und Marburg (DE)
Zero hunger
Openalex Percentile: Top 36%
Immune cells in cancer
DOIOpen Access PDFOpenAlex
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Immunometabolism of T cells and macrophages: Human translational perspectives — Borros Michael Arneth · Immunobiology (2025) | TGRS Research Map | TGRS