Integrating Novel Metabolomics Biomarkers with Multi‐modal Risk Factors in Predicting Mild Cognitive Impairment and Alzheimer's Disease
New molecular biomarkers (from both blood and saliva) perform strongly when integrated into databases with established AD biomarkers and risk factors. Implications include (1) enhancing identification of early mechanistic pathways, (2) importance of conducting integrative and interactive biomarker analyses, especially data-driven, and (3) potential for non-invasive salivary biomarkers for promoting assessment accessibility across diverse communities.
Authors
- Linzy Bohn (ORCID: https://orcid.org/0000-0002-9412-1422)
- Shannon M. Drouin (ORCID: https://orcid.org/0000-0001-8767-5884)
- Roger A. Dixon
- Liang Li
- Shuang Zhao
Institutions
- University of Alberta (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104500
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00