Excitatory neuronal PLCG2 correlates with tau pathology in Alzheimer's disease via the alteration of the autophagy‐lysosomal pathway
These results suggest that repression or dysfunction of PLCG2 may contribute to tau pathology in excitatory neurons of AD, probably via the regulation of the ALP.
Authors
- Hongjun Fu (ORCID: https://orcid.org/0000-0001-5346-7075)
- Hayk Davtyan (ORCID: https://orcid.org/0000-0001-8554-6456)
- Jean Paul Chadarevian (ORCID: https://orcid.org/0000-0002-2478-6592)
- Tae Yeon Kim (ORCID: https://orcid.org/0000-0002-0534-4473)
- Nicholas Sweeney
- Mathew Blurton‐Jones
- Qi Guo
- Diana M Acosta
- Ethan Rose
- Marie‐Amandine Bonte
- Qin Ma
Institutions
- University of California, Irvine (US)
- The Ohio State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104168
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00